Effect of cilnidipine (FRC-8653) on autoregulation of cerebral blood flow.
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- WATANABE Kiyoshi
- Pharmaceuticals Research Laboratories, Fujirebio Inc.
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- DOZEN Masaharu
- Pharmaceuticals Research Laboratories, Fujirebio Inc.
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- HAYASHI Yutaka
- Pharmaceuticals Research Laboratories, Fujirebio Inc.
Bibliographic Information
- Other Title
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- シルニジピン(FRC‐8653)の脳循環自動調節能に及ぼす影響
- シルニジピン FRC-8653 ノ ノウ ジュンカン ジドウ チョウセツノウ
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Abstract
Effect of cilnidipine, a new calcium antagonist, on autoregulation of cerebral blood flow was studied in spontaneously hypertensive rats. Cilnidipine, at doses of 1-100 μg/kg, i.v., showed a hypotensive effect in a dose-dependent manner without affecting regional cerebral blood flows (rCBF) in the cerebral cortex or nucleus caudatus. At intraduodenal doses of 1 or 10 mg/kg, cilnidipine also did not affect rCBFs, while it produced long-lasting hypotension with a slow onset, decreasing blood pressure by about 40% of the pre-administration value at 10 mg/kg. Cilnidipine at a dose of 10 mg/kg, i.d. significantly lowered the lower limit for autoregulation of cerebral blood flow. These findings suggest that autoregulation of cerebral blood flow remains intact even in the excessive hypotension induced with cilnidipine and that the drug shifts the lower limits for autoregulation of cerebral blood flow downward.
Journal
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- Folia Pharmacologica Japonica
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Folia Pharmacologica Japonica 106 (6), 393-399, 1995
The Japanese Pharmacological Society
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Keywords
Details 詳細情報について
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- CRID
- 1390001204271850240
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- NII Article ID
- 10005707793
- 30034987156
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- NII Book ID
- AN00198335
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- COI
- 1:CAS:528:DyaK2MXpvVKhur8%3D
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- ISSN
- 13478397
- 00155691
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- NDL BIB ID
- 3646106
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- PubMed
- 8582687
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed