書誌事項
- タイトル別名
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- Effect of cilnidipine (FRC-8653) on autoregulation of cerebral blood flow.
- シルニジピン FRC-8653 ノ ノウ ジュンカン ジドウ チョウセツノウ
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抄録
Effect of cilnidipine, a new calcium antagonist, on autoregulation of cerebral blood flow was studied in spontaneously hypertensive rats. Cilnidipine, at doses of 1-100 μg/kg, i.v., showed a hypotensive effect in a dose-dependent manner without affecting regional cerebral blood flows (rCBF) in the cerebral cortex or nucleus caudatus. At intraduodenal doses of 1 or 10 mg/kg, cilnidipine also did not affect rCBFs, while it produced long-lasting hypotension with a slow onset, decreasing blood pressure by about 40% of the pre-administration value at 10 mg/kg. Cilnidipine at a dose of 10 mg/kg, i.d. significantly lowered the lower limit for autoregulation of cerebral blood flow. These findings suggest that autoregulation of cerebral blood flow remains intact even in the excessive hypotension induced with cilnidipine and that the drug shifts the lower limits for autoregulation of cerebral blood flow downward.
収録刊行物
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- 日本薬理学雑誌
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日本薬理学雑誌 106 (6), 393-399, 1995
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390001204271850240
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- NII論文ID
- 10005707793
- 30034987156
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- NII書誌ID
- AN00198335
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- COI
- 1:CAS:528:DyaK2MXpvVKhur8%3D
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- ISSN
- 13478397
- 00155691
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- NDL書誌ID
- 3646106
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- PubMed
- 8582687
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可