書誌事項
- タイトル別名
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- Effect of lisuride on experimental cerebral infarction in rats.
- イケイカ セッケッキュウ ユウハツ ラット ノウ コウソク ニ タイスル Li
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抄録
Lisuride is an ergot derivative with central dopaminergic (D2 agonistic) and serotonergic (5-HT1A agonistic) activity. The effect of lisuride on experimental cerebral infarction in rats was investigated. Cerebral infarction was induced by intracarotid infusion of a 50-μl mixture in which deformed and rigid red blood cells treated with hypertonic solution were contained. Lisuride or 0.9 % NaCl was administered subcutaneously 30 min before induction of cerebral infarction. Lisuride (0.01 mg/kg) not only prolonged the survival time of the animals but also suppressed cerebral edema, increase in the electrolytes content and histological damage in the brain. These results suggest that lisuride has a protective effect against cerebral infarction.
収録刊行物
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- 日本薬理学雑誌
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日本薬理学雑誌 98 (6), 449-456, 1991
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390001204272139392
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- NII論文ID
- 130000758818
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- NII書誌ID
- AN00198335
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- ISSN
- 13478397
- 00155691
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- NDL書誌ID
- 3750343
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- PubMed
- 1783326
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可