Antiallergic effects of mequitazine. 2. In vivo experiments.
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- KOHNO Shigekatsu
- Department of Pharmacology, Kyoto Pharmaceutical University
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- YAMAMURA Hideki
- Department of Pharmacology, Kyoto Pharmaceutical University
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- OHATA Katsuya
- Department of Pharmacology, Kyoto Pharmaceutical University
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- TOGAWA Michinori
- Department of Pharmacology, Gifu Pharmaceutical University
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- NAGAI Hiroichi
- Department of Pharmacology, Gifu Pharmaceutical University
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- KODA Akihide
- Department of Pharmacology, Gifu Pharmaceutical University
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- YANAGIHARA Yukiyoshi
- Clinical Research Center for Allergy, National Sagamihara Hospital
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- SHIDA Takao
- Clinical Research Center for Allergy, National Sagamihara Hospital
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- YATSUZUKA Atsushi
- Pharmacological Division, Research Laboratory, Nippon Shoji Kaisha
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- YOSHIDA Yoichi
- Pharmacological Division, Research Laboratory, Nippon Shoji Kaisha
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- TATUMI Hiroshi
- Pharmacological Division, Research Laboratory, Nippon Shoji Kaisha
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- FUJIMURA Hajime
- Kyoto Pharmaceutical University,
Bibliographic Information
- Other Title
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- Mequitazineの抗アレルギー作用 (第2報) In vivoの成績
- Mequitazine ノ コウ アレルギー サヨウ 2 In vivo ノ
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Abstract
Antiallergic effects of mequitazine were investigated in vivo and compared with those of ketotifen and disodium cromoglycate (DSCG). The results obtained were as follows: 1) Mequitazine in doses of 2 and 5 mg/kg given, p.o., 1 hr prior to antigen challenge inhibited dose-dependently the 48-hr passive cutaneous anaphylaxis in rats. Five mg/kg of mequitazine showed almost the same extent of inhibitory activity as that of 1 mg/kg of ketotifen. An i.v. administration of 1 mg/kg DSCG 1 min before antigen challenge also showed a marked inhibition. 2) The experimental asthma induced by challenge with an i.v. injection of antigen in passively sensitized guinea pigs was fairly inhibited by the pretreatment with 5 mg/kg of mequitazine administered p.o., although 2 mg/kg of this drug showed only a slight inhibition. 3) The experimental asthma induced by aerosolized antigen was also fairly inhibited by the pretreatment with 5 mg/kg of mequitazine given p.o.
Journal
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- Folia Pharmacologica Japonica
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Folia Pharmacologica Japonica 92 (2), 159-165, 1988
The Japanese Pharmacological Society
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Keywords
Details 詳細情報について
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- CRID
- 1390001204272581632
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- NII Article ID
- 130000759319
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- NII Book ID
- AN00198335
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- COI
- 1:CAS:528:DyaL1cXlsVaiu7g%3D
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- ISSN
- 13478397
- 00155691
- http://id.crossref.org/issn/00155691
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- NDL BIB ID
- 3200324
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- PubMed
- 2906316
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed