書誌事項
- タイトル別名
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- Antiallergic effects of mequitazine. 2. In vivo experiments.
- Mequitazine ノ コウ アレルギー サヨウ 2 In vivo ノ
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抄録
Antiallergic effects of mequitazine were investigated in vivo and compared with those of ketotifen and disodium cromoglycate (DSCG). The results obtained were as follows: 1) Mequitazine in doses of 2 and 5 mg/kg given, p.o., 1 hr prior to antigen challenge inhibited dose-dependently the 48-hr passive cutaneous anaphylaxis in rats. Five mg/kg of mequitazine showed almost the same extent of inhibitory activity as that of 1 mg/kg of ketotifen. An i.v. administration of 1 mg/kg DSCG 1 min before antigen challenge also showed a marked inhibition. 2) The experimental asthma induced by challenge with an i.v. injection of antigen in passively sensitized guinea pigs was fairly inhibited by the pretreatment with 5 mg/kg of mequitazine administered p.o., although 2 mg/kg of this drug showed only a slight inhibition. 3) The experimental asthma induced by aerosolized antigen was also fairly inhibited by the pretreatment with 5 mg/kg of mequitazine given p.o.
収録刊行物
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- 日本薬理学雑誌
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日本薬理学雑誌 92 (2), 159-165, 1988
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390001204272581632
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- NII論文ID
- 130000759319
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- NII書誌ID
- AN00198335
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- COI
- 1:CAS:528:DyaL1cXlsVaiu7g%3D
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- ISSN
- 13478397
- 00155691
- http://id.crossref.org/issn/00155691
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- NDL書誌ID
- 3200324
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- PubMed
- 2906316
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可