書誌事項
- タイトル別名
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- Insulin secretion in the perfusion of rat pancreas <I>in situ</I>
- Insulin ブンピ ケンキュウ ノ タメ ノ アタラシイ スイ カンリュウ
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抄録
A new perfusion technique was applied to the rat pancreas to elucidate neural mechanisms related to insulin secretion. The pancreas and a part of the gastroduodenal tract were perfused in situ with an artificial perfusion fluid consisting of 5% of rat red blood cells, 4% bovine serum albumin and 0.1 % of glucose and Krebs-Ringer bicarbonate buffer. Stimulation (5-10V, 5 msec, 50 Hz for 5 min) to the right or bilateral cervical vagal nerves produced a significant increase in insulin activity in the perfusate. Acetylcholine (5-10 μg/0.1 ml) added to the perfusion fluid produced a dose-dependent increase in insulin activity in the perfusate, and the responses disappeared after pretreatment with atropine (100 μg/ml in perfusion fluid). After adding noradrenaline or isoproterenol (each 0.1 μg/0.1 ml) to the perfusion fluid, appreciable changes were not apparent.
収録刊行物
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- 日本薬理学雑誌
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日本薬理学雑誌 77 (2), 213-220, 1981
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390001204273316096
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- NII論文ID
- 130000759335
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- NII書誌ID
- AN00198335
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- COI
- 1:CAS:528:DyaL3MXhtlKksbo%3D
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- ISSN
- 13478397
- 00155691
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- NDL書誌ID
- 2344940
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- PubMed
- 7016692
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可