書誌事項
- タイトル別名
-
- Biological activity of lα-hydroxycholecalciferol (1). Effect on intestine and bone in rats.
- カッセイガタ ビタミン D3 ニカンスルケンキュウ 1 1アルファ Hydro
この論文をさがす
説明
Biological activity of 1α-hydroxycholecalciferol was studied in rats. 1α-Hydroxycholecalciferol was found to be more potent and rapidly active than vitamin D in stimulating intestinal calcium transport and calcium mobilization from bone both in normal and vitamin D deficient rats. 1α-Hydroxycholecalciferol was also active in nephrectomized and/or thyroparathyroidectomized rats both in intestine and bone. Although it is well known that 1α-hydroxycholecalciferol is metabolized to lα, 25-dihydroxycholecalciferol in the liver, there is the possibility that the former is active without further metabolism. In rats in which hepatitis was induced by CCl4, 1α-hydroxycholecalciferol was active both in the intestine and in the bone, while it was inactive in hepatectomized rats. These data clearly demonstrate that 1α-hydroxycholecalciferol is not active by itself and must be metabolized in the liver. This idea also shows the lag time in response of rats to 1α-hydroxycholecalciferol as compared with that of 1α, 25-dihydroxycholecalciferol. It was also demonstrated that 1α-hydroxycholecalciferol has more potent antirachitic activity than vitamin D and does not lose its activity with chronic oral administration. In view of these findings, 1α-hydroxycholecalciferol appears to have a good potential for clinical application in cases of renal failure and metabolic bone diseases.
収録刊行物
-
- 日本薬理学雑誌
-
日本薬理学雑誌 74 (2), 267-283, 1978
公益社団法人 日本薬理学会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390001204273777536
-
- NII論文ID
- 30034987809
- 130000758904
-
- NII書誌ID
- AN00198335
-
- COI
- 1:CAS:528:DyaE1cXksFehurw%3D
-
- ISSN
- 13478397
- 00155691
-
- NDL書誌ID
- 1935627
-
- PubMed
- 658840
-
- 本文言語コード
- ja
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可