Pharmacological properties of methylscopolammonium methylsulfate

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  • KASAHARA Akira
    Biological Research Laboratory, Research Laboratories, Daiichi Seiyaku Co., Ltd.
  • KOJIMA Hiroshi
    Biological Research Laboratory, Research Laboratories, Daiichi Seiyaku Co., Ltd.
  • ONODERA Takeshi
    Biological Research Laboratory, Research Laboratories, Daiichi Seiyaku Co., Ltd.
  • HASHIZUME Takeshi
    Biological Research Laboratory, Research Laboratories, Daiichi Seiyaku Co., Ltd.
  • YAMASAKI Terukiyo
    Biological Research Laboratory, Research Laboratories, Daiichi Seiyaku Co., Ltd.
  • TAWARA Katsuhiko
    Biological Research Laboratory, Research Laboratories, Daiichi Seiyaku Co., Ltd.
  • CHIBA Tomomi
    Biological Research Laboratory, Research Laboratories, Daiichi Seiyaku Co., Ltd.

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Other Title
  • Methylscopolammonium methylsuifateの薬理作用
  • Methylscopolammonium methylsulfate ノ ヤクリ サヨウ

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Pharmacological properties of methylscopolam monium methylsulfate (MM) have been examined in comparison with those of butylscopolam monium bromide (BB). Antiacetylc-holineactivity of MM is particularly higher than that of BB although MM possesses also antihistamine, antinicotine, and antiserotonin actions. However, MM does not exhibit the cervical sympathetic ganglion-blocking action in doses of 5 mg/kg (i. v.) or less, while this action of BB is remarkable even in a dose of 3 mg/kg (i. v.) in cats. The curare-like action of MM is also weaker than that of BB. This compound is more potent than BB in dilating the pupil (mice) and in inhibiting the salivary flow elicited by pilocarpine (rabbits). In addition, the effects of MM on cardiovascular and central nervous system are discussed.

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