Methylscopolammonium methylsuifateの薬理作用

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タイトル別名
  • Pharmacological properties of methylscopolammonium methylsulfate
  • Methylscopolammonium methylsulfate ノ ヤクリ サヨウ

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説明

Pharmacological properties of methylscopolam monium methylsulfate (MM) have been examined in comparison with those of butylscopolam monium bromide (BB). Antiacetylc-holineactivity of MM is particularly higher than that of BB although MM possesses also antihistamine, antinicotine, and antiserotonin actions. However, MM does not exhibit the cervical sympathetic ganglion-blocking action in doses of 5 mg/kg (i. v.) or less, while this action of BB is remarkable even in a dose of 3 mg/kg (i. v.) in cats. The curare-like action of MM is also weaker than that of BB. This compound is more potent than BB in dilating the pupil (mice) and in inhibiting the salivary flow elicited by pilocarpine (rabbits). In addition, the effects of MM on cardiovascular and central nervous system are discussed.

収録刊行物

  • 日本薬理学雑誌

    日本薬理学雑誌 67 (1), 100-124, 1971

    公益社団法人 日本薬理学会

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