Studies in β-pyridylcarbinol as a precursor of nicotinamide adenine dinucleotide

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  • KIZU Akira
    Second Department of Internal Medicine, Kyoto Prefectural University of Medicine
  • NAKAMURA Taizo
    Second Department of Internal Medicine, Kyoto Prefectural University of Medicine
  • KATO Syuji
    Second Department of Internal Medicine, Kyoto Prefectural University of Medicine
  • SAWADA Katsunori
    Second Department of Internal Medicine, Kyoto Prefectural University of Medicine
  • IJICHI Hamao
    Second Department of Internal Medicine, Kyoto Prefectural University of Medicine
  • KURIYAMA Kinya
    Department of Pharmacology, Kyoto Prefectural University of Medicine

書誌事項

タイトル別名
  • Studies on .BETA.-pyridylcarbinol as a precursor of nicotinamide adenine dinucleotide.
  • Studies in ベータ pyridylcarbinol as a pre
  • EFFECT OF NEUROLEPTIC DRUGS ON THE CONDITIONED BEHAVIOR AFTER PRETREATMENT WITH α-METHYLTYROSINE OR p-CHLOROPHENYLALANINE

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抄録

The major part of orally administered β-pyridylcarbinol was converted to nicotinic acid in the gastrointestinal tract, whereas that administered intraperitoneally was partially converted to nicotinic acid in the liver. The conversion of this compound to nicotinic acid in both the gastrointestinal tract and liver involved enzymatic processes. The converted nicotinic acid from β-pyridylcarbinol may play a dominant role in the biological actions of β-pyridylcarbinol and possibly involves in the synthesis of NAD via Preiss-Handler's pathway.

収録刊行物

  • Jpn.J.Pharmacol.

    Jpn.J.Pharmacol. 27 (6), 817-821, 1977

    公益社団法人 日本薬理学会

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