Rhythmic contractions induced by vagotomy in the fundus of rat stomach.

KAMATA Katsuo, WATANABE Minoru, KASUYA Yutaka

doi:10.1254/jjp.29.27

Rhythmic contractions induced by vagotomy in the fundus of rat stomach.

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KAMATA Katsuo

Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo
WATANABE Minoru

Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University
KASUYA Yutaka

Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo

書誌事項

タイトル別名

Rhythmic Contractions Induced by Vagoto

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抄録

Continuous rhythmic contractions were observed in longitudinal muscle strips of fundus obtained from the chronically vagotomized rat stomach. These vagotomy-induced rhythmic contractions (VRC) were not blocked either by tetrodotoxin (3 × 10^-6 M) or atropine (3 × 10^-7 M), indicating that the VRC was myogenic in origin. It was also found that the VRC had the following characteristics. 1) The VRC was blocked either by 10^-5 M D600 or by Ca²⁺ deprivation from the medium. 2) On replacement of Na⁺ with sucrose or of K⁺ with Na⁺, the tone of fundus strips was concomitantly elevated with the cessation of the VRC. 3) 10^-5 M ouabain blocked the VRC. 4) The VRC was blocked by cooling. 5) The VRC disappeared under anoxic conditions. Based on these results possible mechanisms of the VRC are discussed in relation to an energy dependent activity of the cell membrane.