A Case of Helicobacter pylori Infection and Rectal MALT Lymphoma Following Erythema Nodosum

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  • YAMAOKA Toshifumi
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences
  • ASHIDA Miwa
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences
  • SHIMIZU Kazuhiro
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences
  • SATO Shinichi
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences
  • CHIN Shunzen
    Second Department of Internal Medicine, Nagasaki University Medical Hospital
  • OHSHIMA Koichi
    Department of Pathology, School of Medicine, Kurume University

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Other Title
  • 結節性紅斑より明らかになったＨｅｌｉｃｏｂａｃｔｅｒ　ｐｙｌｏｒｉ感染および直腸ＭＡＬＴリンパ腫の１例
  • 症例 結節性紅斑より明らかになったHelicobacter pylori感染および直腸MALTリンパ腫の1例
  • ショウレイ ケッセツセイ コウハン ヨリ アキラカ ニ ナッタ Helicobacter pylori カンセン オヨビ チョクチョウ MALT リンパシュ ノ 1レイ

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Description

A 80-year-old Japanese woman who was suffering from erythema with infiltration on the both lower extremities for three months. In this case, histological examination of skin biopsies confirmed the diagnosis of erythema nodosum. Treatment with anti-bacterial infusion and oral NSAIDs were started but they were not effective. To investigate the background of skin lesion, whole body was examined. As results, rectal MALT lymphoma and Helicobacter pylori (H. pyrori)infection on stomach were found. Unfortunately, little is known about relationship between erythema nodosum, and rectal MALT lymphoma, H. pylori infection. However, there are a few reports that rectal MALT lymphoma could be improved slightly after removal of H. pylori. After treatment of H. pylori, the size of rectal MALT lymphoma was reduced and erythema nodosum on the both lower extremities were improved gradually. It is not clarified whether rectal MALT lymphoma and/or H. pylori infection can be cause of erythema nodosum or not. However, based on our clinical case, we would suggest that investigation of malignancy and H. pylori is required and removal of H. pylori might be effective in uncontrolled erythema nodosum.

Journal

  • Nishi Nihon Hifuka

    Nishi Nihon Hifuka 69 (2), 126-130, 2007

    Western Division of Japanese Dermatological Association

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