Five Cases of Lichen Planus-like Keratosis.

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  • Ｌｉｃｈｅｎ　Ｐｌａｎｕｓ‐ｌｉｋｅ　Ｋｅｒａｔｏｓｉｓの５例

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The authors report five cases of lichen planus-like keratosis (LPLK). Four of the five cases had solitary lichenoid lesions with pruritus in the sun-exposed areas of the face, forearm or dorsum of the hand. These eruptions occurred on preexisting pigmented macules. The histopathologic findings showed parakeratosis, liquefaction degeneration of the basal cells, the appearance of Civatte bodies, and as a consequence, the incontinence of pigment. Dense, patchy or band-like T lymphocytes infiltrated in the upper dermis and dermo-epidermal interface. Based on an immunohistochemical analysis in one biopsy, CD 4+ and CD 8+ cells were equally distributed in these infiltrates, and revealed that epidermal keratinocytes in the lesion were strongly immunoreactive for HLA-DR and ICAM-1. These histologic and immunohistochemical findings, in addition to the subsequent regression of the eruptions, may thus suggest that some cell-mediated host defense mechanism plays an important role in the occurrence and rejection reaction of LPLK.

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