Fine Structure of the Genital Paget’s Cell

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  • SHIMODA Nagayoshi
    Department of Dermatology, St. Marianna University School of Medicine
  • MIYAZAKI Kayoko
    Department of Dermatology, St. Marianna University School of Medicine
  • TANAKA Eiko
    Department of Dermatology, St. Marianna University School of Medicine
  • UCHIDA Hiroko
    Department of Dermatology, St. Marianna University School of Medicine
  • FUKUHARA Toshiko
    Department of Dermatology, St. Marianna University School of Medicine
  • CHIBA Toshiko
    Department of Dermatology, St. Marianna University School of Medicine

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Other Title
  • 外陰Paget細胞の微細構造
  • ガイイン Paget サイボウ ノ ビサイ コウゾウ

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Description

Three cases of genital Paget’s disease were observed by electron microscopy. In two cases, Paget’s cells included the presence of secretory granules or glycogen granules and formed lumens and intercellular canaliculi. Desmosomes were small and poorly developed. These findings were suggested as an eccrine sweat gland origin or differentiation toward eccrine apparatus. In the other case, pleomorphic mitochondria, ribosomes and vacuoles were prominent in the cytoplasma of Paget’s cells. Desmosomes were poorly developed and tonofilaments or glycogen granules were difficult to detect in the cytoplasma of Paget’s cells. Thus, we could not determine the origin of Paget’s cell in this case.

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