書誌事項
- タイトル別名
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- Increase in the Level of TIMP-1 in Saliva by Oral Administration of Zinc in Patients with Taste Disorder Due to Zinc Deficiency
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We have already reported that the levels of TIMP-1 (Tissue inhibitor of metalloproteinase) in saliva and Zn2+ in serum were significantly lower in patients with taste disorder than in healthy subjects. This decrease in the level of TIMP-1 was often accompanied by a decrease of zinc in serum. In this study, to test whether administration of zinc is effective in the taste disorder and to establish a method for diagnosis, we have measured and compared TIMP-1 level in saliva before and after treatment for patients with taste disorder. Seven patients (aged 52-82 years) who presented with hypoguesia or loss of taste and were suspected of having zinc deficiency were selected. In these patients, saliva which was secreted by stimulation for 5 minutes was collected and its supernatant was used as the sample to determine TIMP-1 level by Sandwich-Enzyme-Immunoassay (Sandwich EIA) system. The level of TIMP-1 was 130.7±S .D. 57.4ng/ml before treatment and 192.2±S.D. 42.6 ng/ml after treatment (resolution of symptoms), showing a significant difference (p<0.01). These results indicate that taste disorder due to zinc deficiency (including latent zinc deficiency) was related to the decrease of TIMP-1 level in saliva and this was improved by the treatment with zinc administration. Improved symptoms were confirmed by the gustatory test.
収録刊行物
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- 老年歯科医学
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老年歯科医学 18 (1), 3-9, 2003
一般社団法人 日本老年歯科医学会
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詳細情報 詳細情報について
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- CRID
- 1390001204331085568
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- NII論文ID
- 130004300799
- 10012069073
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- NII書誌ID
- AN10023520
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- ISSN
- 18847323
- 09143866
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可