sIL-2Rが高値を示した皮膚原発性未分化大細胞リンパ腫

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  • A case of primary cutaneous anaplastic large cell lymphoma with high levels of sIL-2R

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We here report a case of an 82-year-old man who had been treated with cyclosporine A for psoriasis, with primary cutaneous anaplastic large cell lymphoma (ALCL) showing high levels of sIL-2R. He noticed rapidly developing subcutaneous tumors on the inguinal lesion and the buttocks during 1 month. Serum levels of sIL-2R remarkably increased although no metastatic lesions were detected. Histological examination revealed a dermal tumor composed mainly of large atypical lymphocytes. Immunohistochemical staining showed that tumor cells were positive with CD30 and EMA, and were negative with CD15, anaplastic lymphoma kinase and EBV-associated antibodies. He was treated with both roentgen ray therapy and a local injection of IFN-γ. Respiratory failure due to pleural metastasis was the leading cause of death 8 months after the initial onset. Levels of sIL-2R may be a prognostic marker of primary cutaneous ALCL because serum levels of sIL-2R correlated with the disease activity in this case. [Skin Cancer (Japan) 2004; 19: 355-358]

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