さい帯血から誘導されるアロ抗原反応性細胞傷害性T細胞のさい帯血幹細胞移植における役割
書誌事項
- タイトル別名
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- Role of Alloreactive Cytotoxic T Lymphocytes in Cord Blood Stem Cell Transplantation.
抄録
In patients who developed graft-vs-host disease following allogeneic bone marrow transplantation, the incidence of leukemia relapse is decreased as a result of the graft-vs-leukemia (GVL) effect. In cord blood stem cell transplantation, it is not known if the GVL effect exists. We have investigated the possibility of generating cytotoxic T lymphocytes (CTL) in a mixed lymphocyte culture (MLC). The MLC was set up using cord blood mononuclear cells as responders and the irradiated mononuclear cells of a healthy adult as stimulators. After seven days, the CTL activity was measured. In 17 out of 20 cord blood samples, alloreactive CTL was generated. A simultaneous flow cytometric analysis revealed that CD8+CD45RO+ cells markedly increased following MLC. These in vitro results suggest that the GVL effect may operate in vivo in cord blood stem cell transplantation
収録刊行物
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- 日本小児血液学会雑誌
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日本小児血液学会雑誌 10 (6), 426-431, 1996
特定非営利活動法人 日本小児血液・がん学会
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詳細情報 詳細情報について
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- CRID
- 1390001204341972608
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- NII論文ID
- 130004345470
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- ISSN
- 18844723
- 09138706
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可