さい帯血から誘導されるアロ抗原反応性細胞傷害性Ｔ細胞のさい帯血幹細胞移植における役割

DOI

書誌事項

タイトル別名
  • Role of Alloreactive Cytotoxic T Lymphocytes in Cord Blood Stem Cell Transplantation.

抄録

In patients who developed graft-vs-host disease following allogeneic bone marrow transplantation, the incidence of leukemia relapse is decreased as a result of the graft-vs-leukemia (GVL) effect. In cord blood stem cell transplantation, it is not known if the GVL effect exists. We have investigated the possibility of generating cytotoxic T lymphocytes (CTL) in a mixed lymphocyte culture (MLC). The MLC was set up using cord blood mononuclear cells as responders and the irradiated mononuclear cells of a healthy adult as stimulators. After seven days, the CTL activity was measured. In 17 out of 20 cord blood samples, alloreactive CTL was generated. A simultaneous flow cytometric analysis revealed that CD8+CD45RO+ cells markedly increased following MLC. These in vitro results suggest that the GVL effect may operate in vivo in cord blood stem cell transplantation

収録刊行物

キーワード

詳細情報 詳細情報について

  • CRID
    1390001204341972608
  • NII論文ID
    130004345470
  • DOI
    10.11412/jjph1987.10.426
  • ISSN
    18844723
    09138706
  • 本文言語コード
    ja
  • データソース種別
    • JaLC
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

問題の指摘

ページトップへ