The effectiveness of salivary chromogranin A and amylase as stress indicators in children

DOI 2 Citations 11 References
  • Mitsuhata Chieko
    Department of Pediatric Dentistry, Graduate School of Biomedical Sciences Hiroshima University
  • Suzuki Junji
    Department of Pediatric Dentistry, Graduate School of Biomedical Sciences Hiroshima University
  • Kozai Katsuyuki
    Department of Pediatric Dentistry, Graduate School of Biomedical Sciences Hiroshima University

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  • 小児唾液クロモグラニンＡ，アミラーゼのストレス指標としての有効性

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Abstract

It has been reported that chromogranin A (CgA) cg and amylase (Aml) in saliva could be useful indicators of stress in adults. This study sought to verify whether saliva chromogranin A and amylase may also be used as indices of stress in children. We measured the concentration of CgA and Aml in saliva collected from twenty-four children before and after dental treatment and also performed the Dental Sub-scale of the Children's Fear Schedule (CFSS-DS) examination on all children. The concentration of CgA ranged from 0.59 to 9.95 pmol/mg protein before treatment and 6.80-0.00 pmol/mg protein after treatment. The CgA values decreased in 79.2% of children, and significantly more so in boys than in girls. Children with a high CFSS-DS score also had a high CgA level before treatment and the drop was relatively large compared to children with a low score. We attempted two different methods to measure the Aml level but both produced unstable results. It is concluded that the CgA in saliva might be a useful indicator of stress in children during dental treatment.

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