Magnetite Cationic Liposome (MCLs) を用いた組織内加温療法は家兎VX-7移植舌腫瘍の増殖を抑制する

DOI Web Site 被引用文献9件 参考文献14件

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  • Interstitial Hyperthermia Using Magnetite Cationic Liposomes Inhibit to Tumor Growth of VX-7 Transplanted Tumor in Rabbit Tongue.
  • Interstitial hyperthermia using magnetite cationic liposomes to inhibit tumor growth of VX-7 transplanted tumor in rabbit tongue

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We previously developed a new system of magnetic induction interstitial hyperthermia, implant heating system (IHS), and applied to oral cancer control. To overcome the limitations of this system, the present study dealt with new magnetic induction hyperthermia using Magnetic Cationic Liposomes (MCLs) which are injected into a tumor. We prepared a tongue tumor model using the transplantable rabbit VX-7 cells. MCL was injected into the tumor margins to heat the tumor selectively and induce blood vessel damage by heating. Two separated MCL injection sites were made by using Micro syringe pump and sandwiched the tumor on both sides.<BR>The rabbit in group I (n = 4) were performed hyperthermia, while those in group II (n= 4) were not subjected to magnetic field irradiation as the control. In the experimental rabbits, the temperature in the tumor was as high as 43.0°C. The tumor volumes of irradiated rabbits were significantly smaller than those of the non irradiated ones. The transplanted tumor of experimental rabbits almost completely disappeared following 18 day after treatment. The tongues, removed from irradiated rabbits on 28th day after irradiation, showed no tumor cells and fibrous tissue replacement completely occurred in the implanted tumor area. Tongue muscle adjacent to the MCL injection sites did not exhibit any evidence of inflammation or necrosis. The present study confirmed the effectiveness of interstitial hyperthermia using MCLs against oral carcinoma.

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