Inhibitory Effect of Oxovanadium(IV), Copper(II), and Zinc(II) Ions on the Activity of an Alpha-glucosidase from a Saccharomyces sp
-
- Yoshikawa Yutaka
- Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University,
-
- Hirata Ryoko
- Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University,
-
- Sakurai Hiromu
- Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University,
書誌事項
- タイトル別名
-
- Inhibitory Effect of Oxovanadium(IV), Copper(II), and Zinc(II) Ions on the Activity of an Alpha-glucosidase from a <I>Saccharomyces sp</I>.
この論文をさがす
抄録
We investigated the in vitro and in vivo effects of metal ions on the activity of an alpha-glucosidase (Saccharomyces sp.). CuSO4, ZnSO4, and VOSO4 significantly inhibited the alpha-glucosidase activity in vitro. Additionally, we examined their effects on the blood glucose level by performing oral carbohydrate tolerance tests in both normal ddY mice and streptozotocin-induced diabetic mice. After oral administration of these three metal compounds, the elevation in the blood glucose levels in mice administered disaccharide (sucrose) was significantly suppressed in comparison with untreated mice. On the other hand, the elevation in the blood glucose levels in mice administered monosaccharide (glucose) was not suppressed when such compounds or a vehicle was administered. The results suggested that some metal ions suppress disacharide digestion probably due to the inhibition of the alpha-glucosidase activity in the epithelium of the small intestine.
収録刊行物
-
- Biomedical Research on Trace Elements
-
Biomedical Research on Trace Elements 17 (4), 360-364, 2006
日本微量元素学会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390001204366336384
-
- NII論文ID
- 10018664351
-
- NII書誌ID
- AN10423256
-
- ISSN
- 18801404
- 0916717X
-
- NDL書誌ID
- 8664725
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- CiNii Articles
- KAKEN
-
- 抄録ライセンスフラグ
- 使用不可