Effect of a Large Dose of Di (2-ethylhexyl) phthalate (DEHP) on Hepatic Peroxisome in Cynomolgus Monkeys (Macaca Fascicularis)

DOI Web Site Web Site 参考文献26件
  • Satake Shigeru
    Shin Nippon Biomedical Laboratories Co., Ltd. Department of Veterinary Pathology, Faculty of Agriculture, Iwate University The United Graduate School of Veterinary Sciences, Gifu University
  • Nakamura Chika
    Shin Nippon Biomedical Laboratories Co., Ltd.
  • Minamide Yoshiyuki
    Shin Nippon Biomedical Laboratories Co., Ltd.
  • Kudo Shinobu
    Shin Nippon Biomedical Laboratories Co., Ltd.
  • Maeda Hiroshi
    Shin Nippon Biomedical Laboratories Co., Ltd.
  • Chihaya Yutaka
    Shin Nippon Biomedical Laboratories Co., Ltd.
  • Kamimura Yasuhiro
    Shin Nippon Biomedical Laboratories Co., Ltd.
  • Miyajima Hiroaki
    Shin Nippon Biomedical Laboratories Co., Ltd.
  • Sasaki Jun
    Department of Veterinary Pathology, Faculty of Agriculture, Iwate University
  • Goryo Masanobu
    Department of Veterinary Pathology, Faculty of Agriculture, Iwate University The United Graduate School of Veterinary Sciences, Gifu University
  • Okada Kosuke
    Department of Veterinary Pathology, Faculty of Agriculture, Iwate University The United Graduate School of Veterinary Sciences, Gifu University

この論文をさがす

抄録

To elucidate the effect of a large dose of di (2-ethylhexyl) phthalate (DEHP), a plasticizer and peroxisome proliferator-activated receptor-α (PPARα) agonist, on hepatic peroxisomes, we orally administered 1,000 mg/kg/day, once daily, to 3 male and 4 female cynomolgus monkeys for 28 days consecutively. Light-microscopic and electron microscopic examinations of the liver were carried out in conjunction with measurement of the hepatic fatty acid β-oxidation system (FAOS), carnitine acetyltransferase (CAT) and carnitine palmitoyltransferase (CPT) activities, which are peroxisomal and/or mitochondrial enzyme activities. Electron microscopically, enlargement of the mitochondria was observed with lamellar orientation of the cristae along the major axis. Although the number of peroxisomes showed a tendency to increase when compared with those in a biopsied specimen before treatment, no abnormality in morphology was observed. A slight increase in CPT activity was noted at termination. No changes were noted in hepatic FAOS or CAT activity. In conclusion, although repeated oral treatment of cynomolgus monkeys with a large dose of DEHP induced a subtle increase in the numbers of peroxisomes with slight enlargements of the mitochondria, this low-sensitivity response to peroxisome proliferators in cynomolgus monkeys was considered to be closer to the response in humans than that in rodents.<br>

収録刊行物

参考文献 (26)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ