A case of infectious mononucleosis with a poor prognosis

DOI 9 References
  • Ohnishi Yoshiki
    Department of Otorhinolaryngology and Head and Neck Surgery, Fukuoka University School of Medicine Hospital
  • Tsumatori Keiichirou
    Department of Otorhinolaryngology and Head and Neck Surgery, Fukuoka University School of Medicine Hospital
  • Imamura Akihide
    Department of Otorhinolaryngology and Head and Neck Surgery, Fukuoka Dental College Medical and Dental Hospital
  • Harada Hirofumi
    Department of Otorhinolaryngology and Head and Neck Surgery, Fukuoka Dental College Medical and Dental Hospital
  • Nakagawa Takashi
    Department of Otorhinolaryngology and Head and Neck Surgery, Fukuoka University School of Medicine Hospital

Bibliographic Information

Other Title
  • 血球貪食性リンパ組織球症を合併し死亡した伝染性単核球症の1例

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Description

A 21-year-old man visited a hospital with a fever and a sore throat. Blood examination revealed liver dysfunction, and the patient was suspected of having infectious mononucleosis. He was referred to our hospital, where the initial clinical examination revealed furred palatine tonsils and the blood chemistry showed high aspartate aminotransferase/alanine aminotransferase (AST/ALT) and lactate dehydrogenase (LDH) levels. In addition, the patient had a swelling in the cervical lymph nodes and was diagnosed as having infectious mononucleosis based on positive Epstein-Barr virus (EBV) antibodies. The patient was admitted and symptomatic treatment was started. Approximately 1 week later, the sore throat and inflammatory findings improved, but general malaise was aggravated and splenomegaly and jaundice developed. This was caused by a concurrent hemophagocytic syndrome due to the initial EBV infection, because of which the platelet count decreased rapidly on the 22nd hospital day. Chemotherapy and immunosuppressive therapy were started, but the patient did not improve, resulting in an unfavorable outcome.

Journal

  • Stomato-pharyngology

    Stomato-pharyngology 25 (2), 179-182, 2012

    Japan Society of Stomato-pharyngology

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