Spherical Embolic Agents for Liver Tumor Embolization
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- Osuga Keigo
- Department of Diagnostic and Interventional Radiology, Osaka University Graduate School of Medicine
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- Maeda Noboru
- Department of Diagnostic and Interventional Radiology, Osaka University Graduate School of Medicine
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- Higashihara Hiroki
- Department of Diagnostic and Interventional Radiology, Osaka University Graduate School of Medicine
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- Tanaka Kaishu
- Department of Diagnostic and Interventional Radiology, Osaka University Graduate School of Medicine
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- Kishimoto Kentaro
- Department of Diagnostic and Interventional Radiology, Osaka University Graduate School of Medicine
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- Nakamura Masahisa
- Department of Diagnostic and Interventional Radiology, Osaka University Graduate School of Medicine
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- Ono Yusuke
- Department of Diagnostic and Interventional Radiology, Osaka University Graduate School of Medicine
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- Nakazawa Tetsuro
- Department of Diagnostic Radiology, Osaka Medical Center for Cancer and Cardiovascular Diseases
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- Tomiyama Noriyuki
- Department of Diagnostic and Interventional Radiology, Osaka University Graduate School of Medicine
Bibliographic Information
- Other Title
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- 肝動脈塞栓療法における球状塞栓物質
Description
Recently, three products of calibrated microspheres (Embosphere®, HepaSphere®, and DC-Bead®) have been approved in Japan as embolic agents for hypervascular tumors and arteriovenous malformations. The advantages of these microspheres are that the particles are uniform in size, and easy to inject through a microcatheter. They can travel distally to vessels corresponding to the particle size, and thus, the occlusion level is predictable. Worldwide, the use of these microspheres has been already prevalent in chemoembolization or bland embolization of hepatocellular carcinoma. Two of the approved microspheres (DC-Bead® and HepaSphere®) are also applied as drug-eluting microspheres. However, operators should pay attention to some pitfalls in the use of microspheres. Temporary aggregation and redistribution of microspheres may restore the blood flow of a once occluded vessel. The mechanical properties of drug eluting microspheres may alter upon drug loading and release. Therefore, we need to understand the behavior of each microsphere to obtain the optimal embolic effects. It is also important to investigate the true benefits of microspheres or in what clinical or pathological conditions they will improve the safety and efficacy compared to conventional materials.
Journal
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- The Official Journal of the Japanese Society of Interventional Radiology
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The Official Journal of the Japanese Society of Interventional Radiology 28 (4), 427-435, 2013
The Japanese Society of Interventional Radiology
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Keywords
Details 詳細情報について
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- CRID
- 1390001204435149056
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- NII Article ID
- 130004707480
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- ISSN
- 21856451
- 13404520
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed