パーキンソン病における大脳基底核のバースト振動

DOI 参考文献44件

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  • Bursting Oscillation in Basal Ganglia Associated with Parkinson's Disease

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Symptoms in Parkinson's disease are accompanied by bursting oscillation in the basal ganglia. Although it is clinically important to elucidate the mechanism underlying the oscillatory dynamics, complex interactions among the nuclei in the basal ganglia make it difficult to understand. We review recent hypotheses on the origin of the bursting oscillation, and explain an important role of the subthalamic nucleus and the regions connected to it. We also discuss a computational model on the NMDA-activated burst in the subthalamic nucleus.

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