Innate immune responses in allergy

  • Yoshimoto Tomohiro
    Laboratory of Allergic Diseases, Institute for Advanced Medical Sciences, Hyogo College of Medicine

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Other Title
  • アレルギーにおける自然免疫応答

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We proposed two types of allergic response: IgE-dependent and IgE-independent, and designate these as 'acquired-type allergy' and 'innate-type allergy', respectively. IL-18 and IL-33 are essential regulators for 'innate-type allergy'. Especially, IL-33 stimulates both innate (basophils, mast cells, or group 2 innate lymphoid cells) and acquired (Th2 cells) allergy-related cells to induce and/or augment Th2 cytokine production, which leads to eosinophilic inflammation in vivo. Thus, IL-33 is an essential regulator for both 'innate-type allergy' and 'acquired-type allergy', and might be a therapeutic target for allergic diseases.<br>



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