培養細胞を用いた毒性テストについて

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タイトル別名
  • Toxicity Tests Using Cultured Cells.
  • バイヨウ サイボウ オ モチイタ ドクセイ テスト ニ ツイテ

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説明

Toxicological studies using cultured mammalian cells are extremely useful and expected to be important alternatives to animal tests and experiments. There are various types of cultured cell experiments for various purposes, which need strict step-wise validation studies when used as the routine tests. The following test methods under validation studies are explained here ; direct cytotoxicity test, cytotoxicity test using cultured myotubes for intramuscular injection drugs, mouse lymphoma assay for gene mutation, in vitro cell transformation test for carcinogens and tumor promoters, and metabolic cooperation assay for tumor promoters. In order to achieve alternatives of animal experiments, researchers engaging in toxicological studies and recognizing their necessity are required to cooperate together for the further development of the experimental methods.

収録刊行物

  • 衛生化学

    衛生化学 42 (6), 443-452, 1996

    公益社団法人 日本薬学会

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