An X-chromosome RNA-binding motif protein (RBMX) is required for proper kinetochore formation

DOI Web Site 参考文献24件
  • Lee Mei Hann
    Department of Biotechnology, Graduate School of Engineering, Osaka University
  • Lin Linyen
    Research Center for Ultra-High Voltage Electron Microscopy, Osaka University
  • Takata Hideaki
    Department of Biotechnology, Graduate School of Engineering, Osaka University
  • Morimoto Akihiro
    Department of Biotechnology, Graduate School of Engineering, Osaka University
  • Uchiyama Susumu
    Department of Biotechnology, Graduate School of Engineering, Osaka University
  • Matsunaga Sachihiro
    Department of Biotechnology, Graduate School of Engineering, Osaka University
  • Fukui Kiichi
    Department of Biotechnology, Graduate School of Engineering, Osaka University

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抄録

RBMX is an RNA-binding motif protein identified as a component of purified human metaphase chromosomes. We have analyzed the functional significance of RBMX by electron microscopy (EM) in combination with RNA interference (RNAi). We revealed that depletion of RBMX results in the accumulation of mitotic cells. EM investigation further showed that RBMX depletion leads to an increase in the fuzzy ball structure that is reminiscent of the prekinetochore. It is most probably due to the result of disruption at early stages of kinetochore maturation, so that kinetochore differentiation into the authentic trilaminar morphology is disturbed. The present EM data illuminated the importance of RBMX in kinetochore formation for subsequent stable microtubules interaction.

収録刊行物

  • Chromosome Science

    Chromosome Science 14 (1+2), 17-21, 2011

    一般社団法人 染色体学会

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