Evaluation of the Effectiveness of Epidemiological Surveillance using Anti-influenza Drugs Detected in Sewage Influent

  • AZUMA Takashi
    Research Center for Environmental Quality Management, Graduate School of Engineering, Kyoto University
  • SUGAWARA Tamie
    Infectious Disease Surveillance Center, National Institute of Infectious Disease, Ministry of Health, Labour and Welfare, Toyama Research Center
  • NAKADA Norihide
    Research Center for Environmental Quality Management, Graduate School of Engineering, Kyoto University
  • YAMASHITA Naoyuki
    Research Center for Environmental Quality Management, Graduate School of Engineering, Kyoto University
  • MINO Yoshiki
    Graduate School of Pharmaceutical Sciences, Osaka University of Pharmaceutical Sciences
  • TANAKA Hiroaki
    Research Center for Environmental Quality Management, Graduate School of Engineering, Kyoto University
  • OHKUSA Yasushi
    Infectious Disease Surveillance Center, National Institute of Infectious Disease, Ministry of Health, Labour and Welfare, Toyama Research Center

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Other Title
  • 下水中の抗インフルエンザ薬成分を用いた疫学調査手法の検討
  • カスイチュウ ノ コウインフルエンザヤク セイブン オ モチイタ エキガク チョウサ シュホウ ノ ケントウ

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In this study, the number of influenza patients treated with anti-influenza drugs oseltamivir and zanamivir during the influenza outbreak seasons in 2010-2011 and 2011-2012 in Kyoto district was estimated by monitoring drug concentrations in influent at sewage treatment plants. The results were positively correlated with values estimated by the Pharmacy Surveillance Institute of the Infectious Disease Surveillance Center in the National Institute of Infectious Disease, Japan. Our estimation method of the number of influenza patients has the potential to be used as a tool for epidemiological surveillance of other infectious diseases.

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