Specific Inhibition of Hypoxia-inducible Factor (HIF)-1α Activation and of Vascular Endothelial Growth Factor (VEGF) Production by Flavonoids
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- Hasebe Yuki
- Department of Microbiology, Showa University of Pharmaceutical Sciences
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- Egawa Kiyoshi
- Department of Microbiology, Showa University of Pharmaceutical Sciences
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- Yamazaki Yoko
- Institute of Microbial Chemistry, Tokyo
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- Kunimoto Setsuko
- Institute of Microbial Chemistry, Tokyo
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- Hirai Yasuaki
- Department of Pharmacognosy and Phytochemistry, Showa University of Pharmaceutical Sciences
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- Ida Yoshiteru
- Department of Pharmacognosy and Phytochemistry, Showa University of Pharmaceutical Sciences
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- Nose Kiyoshi
- Department of Microbiology, Showa University of Pharmaceutical Sciences
書誌事項
- タイトル別名
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- Specific Inhibition of Hypoxia-inducible Factor (HIF)-1.ALPHA. Activation and of Vascular Endothelial Growth Factor (VEGF) Production by Flavonoids
- Specific Inhibition of Hypoxia inducible Factor HIF 1 アルファ Activation and of Vascular Endothelial Growth Factor VEGF Production by Flavonoids
この論文をさがす
抄録
Screening using a reporter under the control of the hypoxia-response element (HRE) identified several flavonoids and homoisoflavonoids that inhibit the activation of HRE under hypoxic conditions. Among various compounds, isorhamnetin, luteolin, quercetin, and methyl ophiopogonanone B (MOB) were effective at 3 to 9 μg/ml in inhibiting the reporter activity. The expression of vascular endothelial growth factor (VEGF) mRNA during hypoxia was also inhibited by MOB in HepG2 cells, but the effective doses were 10 to 20 μg/ml. MOB caused destabilization of hypoxia-inducible factor (HIF)-1α, as revealed by Western blotting, that was dependent on proteasome activity and the tumor suppressor, p53. The tubular formation and migration of human umbilical vein endothelial cells was also inhibited by MOB. MOB is expected to act as an inhibitor of angiogenesis.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 26 (10), 1379-1383, 2003
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204627651072
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- NII論文ID
- 110003608309
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- NII書誌ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 6696326
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- PubMed
- 14519939
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可