Role of 5-Hydroxytryptamine2C Receptors in Marble-Burying Behavior in Mice

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  • Egashira Nobuaki
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University Department of Pharmacy, Kyushu University Hospital
  • Okuno Ryoko
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
  • Shirakawa Atsunori
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
  • Nagao Masaki
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
  • Mishima Kenichi
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
  • Iwasaki Katsunori
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
  • Oishi Ryozo
    Department of Pharmacy, Kyushu University Hospital
  • Fujiwara Michihiro
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University

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We examined the role of 5-hydroxytryptamine2C (5-HT2C) receptors in marble-burying behavior in mice. When administered alone, the selective 5-HT2C agonist WAY161503 (3 mg/kg) inhibited marble-burying behavior. Moreover, the selective 5-HT2C antagonist SB242084 (3 mg/kg) reversed the inhibition of marble-burying behavior by 2,5-dimethoxy-4-iodoamphetamine (DOI) (1 mg/kg) or WAY161503 (3 mg/kg). Similarly, SB242084 (1 mg/kg) reversed the inhibition of marble-burying behavior by fluvoxamine (30 mg/kg) or paroxetine (3 mg/kg). These results suggest that 5-HT2C receptors play a role in marble-burying behavior in mice.

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