Possible Involvement of Ubiquitin Ligase HRD1 Insolubilization in Amyloid .BETA. Generation
-
- Kaneko Masayuki
- Department of Pharmacology, Faculty of Pharmaceutical Sciences, Chiba Institute of Science
-
- Saito Ryo
- Department of Pharmacology, Faculty of Pharmaceutical Sciences, Chiba Institute of Science
-
- Okuma Yasunobu
- Department of Pharmacology, Faculty of Pharmaceutical Sciences, Chiba Institute of Science
-
- Nomura Yasuyuki
- Laboratory of Pharmacotherapeutics, Yokohama College of Pharmacy
Bibliographic Information
- Other Title
-
- Possible Involvement of Ubiquitin Ligase HRD1 Insolubilization in Amyloid β Generation
Search this article
Description
Endoplasmic reticulum (ER)-associated degradation (ERAD) selectively retro-transports and degrades unfolded proteins accumulated in the ER. We have demonstrated that the ubiquitin ligase HRD1 involved in ERAD was significantly decreased in the cerebral cortex of Alzheimer’s disease patients. Furthermore, the HRD1 level was negatively correlated with amyloid β (Aβ) production levels. Here we found that the HRD1 protein level decrease was due to its insolubilization. Moreover, these protein levels extracted from detergent insoluble fraction were positively correlated with those of SEL1L and Aβs (Aβ40 and Aβ42). Thus, the insolubilization-induced decrease in the HRD1 and SEL1L levels might involve in Aβ generation.
Journal
-
- Biological and Pharmaceutical Bulletin
-
Biological and Pharmaceutical Bulletin 35 (2), 269-272, 2012
The Pharmaceutical Society of Japan
- Tweet
Details 詳細情報について
-
- CRID
- 1390001204631878656
-
- NII Article ID
- 130001872305
-
- NII Book ID
- AA10885497
-
- COI
- 1:STN:280:DC%2BC387pt1yltw%3D%3D
-
- ISSN
- 13475215
- 09186158
-
- NDL BIB ID
- 023409708
-
- PubMed
- 22293361
-
- Text Lang
- en
-
- Data Source
-
- JaLC
- IRDB
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
-
- Abstract License Flag
- Disallowed