Possible Involvement of Ubiquitin Ligase HRD1 Insolubilization in Amyloid β Generation
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- Kaneko Masayuki
- Department of Pharmacology, Faculty of Pharmaceutical Sciences, Chiba Institute of Science
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- Saito Ryo
- Department of Pharmacology, Faculty of Pharmaceutical Sciences, Chiba Institute of Science
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- Okuma Yasunobu
- Department of Pharmacology, Faculty of Pharmaceutical Sciences, Chiba Institute of Science
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- Nomura Yasuyuki
- Laboratory of Pharmacotherapeutics, Yokohama College of Pharmacy
書誌事項
- タイトル別名
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- Possible Involvement of Ubiquitin Ligase HRD1 Insolubilization in Amyloid .BETA. Generation
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説明
Endoplasmic reticulum (ER)-associated degradation (ERAD) selectively retro-transports and degrades unfolded proteins accumulated in the ER. We have demonstrated that the ubiquitin ligase HRD1 involved in ERAD was significantly decreased in the cerebral cortex of Alzheimer’s disease patients. Furthermore, the HRD1 level was negatively correlated with amyloid β (Aβ) production levels. Here we found that the HRD1 protein level decrease was due to its insolubilization. Moreover, these protein levels extracted from detergent insoluble fraction were positively correlated with those of SEL1L and Aβs (Aβ40 and Aβ42). Thus, the insolubilization-induced decrease in the HRD1 and SEL1L levels might involve in Aβ generation.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 35 (2), 269-272, 2012
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204631878656
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- NII論文ID
- 130001872305
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- NII書誌ID
- AA10885497
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- COI
- 1:STN:280:DC%2BC387pt1yltw%3D%3D
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 023409708
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- PubMed
- 22293361
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- NDL
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- PubMed
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- 使用不可