Development of nucleic acid delivery system using lipid nanoparticles

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  • Okamoto Ayaka
    Department of Medical Biochemistry, University of Shizuoka School of Pharmaceutical Sciences
  • Asai Tomohiro
    Department of Medical Biochemistry, University of Shizuoka School of Pharmaceutical Sciences
  • Oku Naoto
    Department of Medical Biochemistry, University of Shizuoka School of Pharmaceutical Sciences

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Other Title
  • 脂質ナノ粒子を用いた核酸医薬デリバリー
  • シシツ ナノ リュウシ オ モチイタ カクサン イヤク デリバリー

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Recently, as more than 1 in 3 people get cancer in their lifetime in Japan, the development of innovative anticancer drugs have been desired. We focused on small interfering RNA (siRNA) and microRNA (miRNA) as a candidate of next generation anticancer drugs because they can induce cancer cell death selectively in a sequence-dependent manner. Because these small RNAs are not stable in the body and not permeable across cell membrane, it is necessary to develop drug delivery systems. We have revealed that lipid nanoparticle-mediated delivery of small RNAs is useful for selective delivery to tumors, resulting in induction of RNA interference-mediated gene silencing in vivo. In this review, we summarize our recent findings on small RNA delivery with polycation liposomes, or with lipid nanoparticles.

Journal

  • Drug Delivery System

    Drug Delivery System 31 (1), 54-61, 2016

    THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM

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