Development of Selective Detection Methods for Pharmaceutical and Biological Compounds Based on Fluorescence and Chemiluminescence Techniques and Its Application for Biomedical Analyses

DOI IR HANDLE Web Site Web Site 51 References

Bibliographic Information

Other Title
  • 蛍光・化学発光反応に基づく高選択的検出法の開発と生体分析への応用
  • ケイコウ ・ カガク ハッコウ ハンノウ ニ モトズク コウセンタクテキ ケンシュツホウ ノ カイハツ ト セイタイ ブンセキ エ ノ オウヨウ

Search this article

Description

In order to provide therapeutic advice or diagnosis, it is important to determine the concentration of a pharmaceutical agent or biomarker in biological fluids. However, it is difficult to determine a target analyte selectively due to interferences derived from a large number of co-existing biological components. In order to overcome this problem, we have developed selective detection methods for pharmaceutical agent or biomarker in the presence of biological components using a specific structure or characteristic of the target analyte. Among related studies, this review describes two principle methods : namely (1) selective fluorescence derivatization methods for aryl halide or terminal double bond based on palladium coupling reaction, and (2) selective detection methods for quinone by chemiluminescence and fluorescence reactions of utilizing the specific characteristics of quinone.

Journal

  • BUNSEKI KAGAKU

    BUNSEKI KAGAKU 61 (7), 583-590, 2012

    The Japan Society for Analytical Chemistry

References(51)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top