癌性胸水を伴わない肺癌患者胸腔内マクロファージによる胸腔内リンパ球・末梢血リンパ球のＬＡＫ活性発現に対する調節能

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  • Regulation of LAK Activity from Pleural Cavity Lymphocytes and Peripheral Blood Lymphocytes by Pleural Cavity Macrophages in Lung Cancer Patients without Malignant Effusion.

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The ability of pleural cavity lymphocytes (PLY) and peripheral blood lymphocytes (BLY) to generate lymphokine (IL-2)-activated killer (LAK) activity and of pleural cavity macrophages (PCM) and peripheral blood monocytes (Mo) to regulate LAK induction were examined. Purified PLY, BLY (>99%) and PCM, Mo (>90%) were separated by two-step discontinuous gradient centrifugation. LAK activity against Daudi cells was measured by 4-hr 51Cr release assay. Results showed that non-stimulated PCM and LPS-stimulated PCM could up-regulate LAK activity from BLY significantly (p<0.05, p<0.05). LAK activity induced from PLY could be up-regulated significantly by only LPS-stimulated PCM (p<0.05). LAK activity induced from BLY could be up-regulated significantly by only non-stimulated Mo (p<0.01). Non-stimulated Mo up-regulated LAK activity induced from BLY significantly more than LPS-stimulated Mo (p<0.05). These findings indicate that the function of PCM to regulate LAK activity from BLY and PLY is different from those of Mo and that PCM is the most effective cell against the invasion of cancer cells into the pleural cavity of lung cancer patients.

収録刊行物

  • 肺癌

    肺癌 34 (3), 371-376, 1994

    特定非営利活動法人 日本肺癌学会

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