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Genetic Mapping of Candidate Gene Influencing the Defect of Tooth in EL Congenic Mice

  • Morita Wataru
    Department of Pediatric Dentistry, Nihon University School of Dentistry at Matsudo
  • Shimizu Takehiko
    Department of Pediatric Dentistry, Nihon University School of Dentistry at Matsudo
  • Maeda Takahide
    Department of Pediatric Dentistry, Nihon University School of Dentistry at Matsudo

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Other Title
  • マウス欠如歯原因遺伝子の染色体マッピング

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Abstract

EL/Sea mice have 100% incidence of the defect of the third molars (M3), and are used as an animal model for the study of missing teeth.<BR>We previously have reported that a region between 123.1 Mega base pair (Mbp) and 136.9 Mbp in chromosome 3 was involved in the defect of M3 of EL, and named this gene absence of the third molars (am3).<BR>The purpose of the present study is to narrow the am3 region causing the absence of M3 in EL/Sea mice, and to identify the major candidate gene.<BR>For this reason we generated EL/Sea congenic mice with the am3 region in which the restricted interval of chromosome 3 was replaced by a MSM/Msf-derived homologue.<BR>We also examined the location of chromosomal recombination in the am3 region by newly produced DNA maker.<BR>By comparing genotypes and phenotypes of EL congenic mice, we clearly mapped the am3 locus within an approximately 1000 kbp region between 130.7 Mbp and 131.7 Mbp.<BR>This region includes 5 genes, Lefl, Hadh, Cyp2u1, Sgms2 and Papss 1 as candidate genes for am3.

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