2004 年 WHO 分類に基づく病理組織診断による尿細胞診評価の試みおよび Liquid-based cytology (LBC) 標本と従来法標本の比較研究

  • 平 紀代美
    独立行政法人国立病院機構北海道がんセンター臨床検査科
  • 東 学
    独立行政法人国立病院機構北海道がんセンター臨床検査科
  • 奥山 大
    独立行政法人国立病院機構北海道がんセンター臨床検査科
  • 中島 真奈美
    独立行政法人国立病院機構北海道がんセンター臨床検査科
  • 鈴木 宏明
    独立行政法人国立病院機構北海道がんセンター病理診断科
  • 山城 勝重
    独立行政法人国立病院機構北海道がんセンター病理診断科

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タイトル別名
  • A trial of evaluating urine cytology based on the 2004 WHO classification, and comparative study of liquid-based cytology preparation and conventional ones

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Objective : To verify the value of liquid-based cytology (LBC) in urine cytology and to determine differences in cytological features between conventional and LBC preparations.<br>Study Design : Subjects numbered 114 with primary bladder cancer undergoing preoperative urine cytology. This was, first, to determine the relationship between the 2004 World Health Organization histological classification of urinary tract tumors and the results of urine cytology and, second, to compare the sensitivities of using (1) the conventional preparation alone and (2) both the conventional preparation and LBC with CytoRich Red. We also reexamined the cytological features of the two preparations.<br>Results : Sensitivity in urine cytology differed in histological surface growth patterns. Sensitivity using both types of preparation was 84.3% and that using conventional preparation alone was 61.1%. Adding the LBC preparation clearly improved that using the conventional preparation alone, especially for low-grade tumors. Tumor cells, including large clustered cells on a LBC preparation, were increased, resulting in more successful cytodiagnosis. False-positive cases did not increase in number. Although cells appeared similar to those of LBC applied to other specimens, the distinction from conventional preparations was minimal.<br>Conclusion : The concurrent use of LBC preparations raised urine cytology sensitivity.

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