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<i>TET2</i> mutation in diffuse large B-cell lymphoma

  • Kubuki Yoko
    Department of Transfusion and Cell Therapy, University of Miyazaki Hospital Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki
  • Yamaji Takumi
    Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki
  • Hidaka Tomonori
    Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki Oncology Unit, University of Miyazaki Hospital
  • Kameda Takuro
    Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki
  • Shide Kotaro
    Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki
  • Sekine Masaaki
    Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki
  • Kamiunten Ayako
    Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki
  • Akizuki Keiichi
    Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki
  • Shimoda Haruko
    Department of Transfusion and Cell Therapy, University of Miyazaki Hospital Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki
  • Tahira Yuuki
    Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki
  • Nakamura Kenichi
    Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki
  • Abe Hiroo
    Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki
  • Miike Tadashi
    Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki
  • Iwakiri Hisayoshi
    Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki
  • Tahara Yoshihiro
    Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki Oncology Unit, University of Miyazaki Hospital
  • Sueta Mitsue
    Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki
  • Yamamoto Shojiro
    Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki
  • Hasuike Satoru
    Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki
  • Nagata Kenji
    Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki Liver Disease Center, University of Miyazaki Hospital
  • Kitanaka Akira
    Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki
  • Shimoda Kazuya
    Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki

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Abstract

<p>Ten-eleven translocation-2 (TET2) mutation is frequently observed in myeloid malignancies, and loss-of-function of TET2 is essential for the initiation of malignant hematopoiesis. TET2 mutation presents across disease entities and was reported in lymphoid malignancies. We investigated TET2 mutations in 27 diffuse large B-cell lymphoma (DLBCL) patients and found a frameshift mutation in 1 case (3.7%). TET2 mutation occurred in some populations of DLBCL patients and was likely involved in the pathogenesis of their malignancies.</p>

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