Effect of Bucillamine on Rheumatoid Arthritis in a Dog

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  • ブシラミンが効果を示した犬慢性関節リウマチの1例
  • ブシラミン ガ コウカ オ シメシタ イヌ マンセイ カンセツ リウマチ ノ

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A 7-year-old female Toy Poodle weighing 2.1kg showed joint swelling and angular deformity with pain and lameness. Radiography revealed luxation with severe destruction of joints and periarticular soft tissue swelling. Hyperglobulinemia with increased levels of alpha2, beta and gammaglobulin fractions was observed. After administrating of bucillamine, an immunomodulator, clinical signs of affected joints were significantly improved in accordance with decreasing gamma globulin, suggesting that immunologic mechanism might be involved in this case of canine rheumatoid arthritis.

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