体外循環施行前後ではアミオダロンおよびアミオダロン代謝物の血中濃度変化は認められない ~ 1症例報告 ~

書誌事項

タイトル別名
  • No Change in Serum Concentrations of Amiodarone and Desethyl-amiodarone in Vicinity of Cardiopulmonary Bypass Surgery : A case report

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抄録

It has been reported that cardiopulmonary bypass (CPB) surgery influences the pharmacokinetics of various drugs. In this study, we investigated serum concentrations of amiodarone (AMD) and desethyl-amiodarone (DEA), the amiodarone metabolite, in the vicinity of CPB. Our patient was taking amiodarone tablets because other antiarrhythmic agents had been ineffective against premature ventricular contraction and nonsustained ventricular tachycardia. The patient underwent aortic valve replacement under CPB for aortic stenosis, and serum concentrations of AMD and DEA were measured in the vicinity of the CPB surgery before and after it. There was no change in the serum concentrations (before CPB surgery; AMD : 0.71 μg/mL, DEA : 0.47 μg/mL, after CPB surgery; AMD : 0.85 μg/mL, DEA : 0.46 μg/mL). During and after surgery, no atrial or ventricular tachyarrhythmia was observed.<br>We considered that serum concentrations of AMD and DEA were not influenced by CPB because of amiodarone's high protein binding ratio and large distribution volume, which are characteristics of this drug.

収録刊行物

  • 医療薬学

    医療薬学 37 (12), 707-711, 2011

    一般社団法人日本医療薬学会

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