種々の炎症反応モデルに及ぼす免疫調節剤lobenzarit disodium (CCA) の影響

種村 満, 中野 利昭, 大杉 義征, 池田 勇五, 畑 俊一, 高垣 善男

doi:10.2492/jsir1981.4.3_239

種々の炎症反応モデルに及ぼす免疫調節剤lobenzarit disodium (CCA) の影響

DOI

種村満

中外製薬 (株) 新薬研究所
中野利昭

中外製薬 (株) 新薬研究所
大杉義征

中外製薬 (株) 新薬研究所
池田勇五

中外製薬 (株) 新薬研究所
畑俊一

中外製薬 (株) 新薬研究所
高垣善男

中外製薬 (株) 新薬研究所

書誌事項

タイトル別名

<I>Effect of an immunomodulator, ‘lobenzarit disodium’ (CCA), on various experimental models of inflammation</I>

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説明

Lobenzarit disodium (CCA; disodium 4-chloro-2, 2'-iminodibenzoate) had no inhibitory effect on carrageenan eodema, cotton pellet granulomatosis, acetic acid writhing test, hot plate test and passive cutaneous anaphylaxis reaction. CCA also did not show an inhibitionin vitroPGE₂biosynthesis. These results clearly show that CCA is quite different from mefenamic acid in its biological activities while the chemical structures of both are similar. The suppressive and inhibitory effects of CCA on the immunologically-induced murine inflammation such as adjuvant arthritis and methylated bovine serum albumin-induced arthritis in rats or spontaneously occurred autoimmune diseases in NZB/NZW F₁and MRL/1 mice, were thought to be derived from its immunomodulating activity.