Evaluation of toxicities of 7-hydroxyisotrichodermin and 8-hydroxyisotrichodermin, shunt intermediates in the biosynthetic grid of deoxynivalenol, by using a sensitive yeast assay
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- Kamata Kentaro
- Graduate School of Engineering, Toyo University
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- Tanaka Akira
- Graduate School of Engineering, Toyo University
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- Maeda Kazuyuki
- Department of Biological Mechanisms and Functions, Graduate School of Bioagricultural Sciences, Nagoya University
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- Takushima Ryo
- Graduate School of Engineering, Toyo University
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- Sato Hiroki
- Department of Science and Engineering, Toyo University
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- Aikawa Shunichi
- Research Institute of Industrial Technology, Toyo University
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- Yoshida Yasuhiko
- Graduate School of Engineering, Toyo University Department of Science and Engineering, Toyo University Research Institute of Industrial Technology, Toyo University Bio-Nano Electronics Research Centre, Toyo University
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- Kimura Makoto
- Department of Biological Mechanisms and Functions, Graduate School of Bioagricultural Sciences, Nagoya University
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- Takahashi-Ando Naoko
- Graduate School of Engineering, Toyo University Department of Science and Engineering, Toyo University Research Institute of Industrial Technology, Toyo University Bio-Nano Electronics Research Centre, Toyo University
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説明
Fusarium graminearum causes a disease of wheat and barley known as Fusarium head blight. It contaminates the grains with trichothecene mycotoxins such as deoxynivalenol (DON). As shunt intermediates in the DON biosynthetic pathway, 7-hydroxyisotrichodermin (7-HIT) and 8-hydroxyisotrichodermin (8-HIT) are known. However, their activities have not been previously evaluated. In this study, we performed toxicity assays of these trichothecenes by using a sensitive yeast bioassay that we have recently established. The IC50 of 7-HIT and 8-HIT were in the range of 20-40 μg/ml, while the IC50 of DON was approximately 1.5 μg/ml. Although the toxicity of these shunt metabolites remains to be investigated in animal systems, our present data indicate that 7-HIT and 8-HIT may not be major issues that require regulation in agricultural products.
収録刊行物
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- マイコトキシン
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マイコトキシン 65 (1), 7-9, 2015
日本マイコトキシン学会
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詳細情報 詳細情報について
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- CRID
- 1390001204786437888
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- NII論文ID
- 130005066149
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- NII書誌ID
- AA12721071
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- ISSN
- 18810128
- 02851466
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- NDL書誌ID
- 027209609
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可