Efficacy of CE14 (human placenta preparation) in a double blind trial on chronic liver diseases

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Other Title
  • 二重盲検によるCE-14の慢性肝疾患に対する効果
  • ニジュウ モウケン ニ ヨル CE-14 ノ マンセイ ギモ シッカン ニ タイスル コウカ

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Abstract

CE14 (L), hydrolized cold human placenta, contains various amino acids. As the action of L, lipotropic function, accelerating activity on tissue respiration, action promoted hepatic regeneration, and others were already reported by the experimental studies. The present study was to know whether or not L was an effective drug for the treatment of chronic liver diseases. The patients were divided in two groups at random in double blind method. Saline solution was used as placebo. In group 1, the injection of L was performed for two weeks. After that the placebo was used for two weeks, and the study was repeated once more. Group 2 received the injection of placebo at first. For the next two weeks they were injected L. After that the process was done once more the same as group 1. The liver function tests were examined every two weeks, and their levels before and after two weeks were compared. GOT and GPT in both groups decreased in the period of the administration of L and it was statistically significant. In contrast, no significant decreases of GOT and GPT were obtained in the placebo period of both groups. Consequently, it is suggested that L is effective in patients with chronic liver diseases.

Journal

  • Kanzo

    Kanzo 15 (3), 162-171, 1974

    The Japan Society of Hepatology

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