無症候性肝内型原発性硬化性胆管炎の１例

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タイトル別名
  • Asymptomatic intrahepatic sclerosing cholangitis.

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抄録

A 54 y.o. woman, who is completely asymptomatic, is reported to have primary sclerosing cholangitis (PSC) localized in the intrahepatic biliary tree alone. The liver function disorder was noticed by chance, representing a marked cholestatic pattern with slightly elevated IgM and weakly positive anti-mitochondrial antibody (AMA). The liver histology showed bile duct loss and ductular proliferation with lympho-plasmocytic infiltration in the portal tract. She was then diagnosed as a probable primary biliary cirrhosis (PBC) and treated with D-penicillamine. After about 4 years, during which the levels of the bile duct enzymes and IgM gradually dropped, her liver disease was re-evaluated. The liver histology showed mild ductular changes and portal fibrosis. AMA was not detectable. ERCP showed a diffuse costricturing and beaded appearances of the intrahepatic biliary tree, whereas the extrahepatic biliary system was normal. The diagnosis of intrahepatic PSC was finally made.

収録刊行物

  • 肝臓

    肝臓 27 (4), 515-522, 1986

    一般社団法人　日本肝臓学会

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