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- 柏村 勝利
- 岩手医科大学 内科学第1講座
書誌事項
- タイトル別名
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- Experimental and Clinical Studies on the Effect of Urease Inhibitor on Hyperammoniemia
- コウアンモニア チ ニ タイスル ウレアーゼ ソガイザイ ノ コウカ ニ カンスル ジッケンテキ , リンショウテキ ケンキュウ
この論文をさがす
説明
In order to clarify the effect of urease inhibitor, acetohydroxamic acid (AHA), caprylohydroxamic acid (CHA) and nicotinohydroxamic acid (NHA) on hyperammoniemia, dogs with Eck fistula and rats with CCl4 hepatic damage associated with hyperammoniemia were use<BR>Clinically, oral administration of CHA was made in 8 cirrhotic patients with hyperammoniemia. The blood ammonia decreased significantly after the oral or intravenous administration of urease inhibitors in the experimental animals, and the decrease of blood ammonia was noted immediately after an intravenous administration. By the oral or intravenous administration of AHA or CHA in experimental rats, hyperammoniemia improved after the decrease of mucosal urease activities. The blood ammonia decreased in 5 out of 8 cirrhotic patients with hyperammoniemia. The effect of urease inhibitors on hyperammoniemia is thought to be systemic and to be brought about by the inhibition of intestinal mucosal urease activities.
収録刊行物
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- 肝臓
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肝臓 15 (3), 172-185, 1974
一般社団法人 日本肝臓学会
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詳細情報 詳細情報について
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- CRID
- 1390001204795383424
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- NII論文ID
- 130000871975
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- NII書誌ID
- AN00047770
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- ISSN
- 18813593
- 04514203
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- NDL書誌ID
- 7519751
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可