ラットオペラント行動に及ぼすビタミンB1および関連物質の影響

岡崎 雅子, 安原 一, 笠原 多嘉子, 坂本 浩二

doi:10.14930/jsma1939.37.161

Effect of B₁and related agents on the operant behaviors in rats was studied, using a commercially available apparatus. Two schedules of the food reinforcement with a fixed ratio (FR-30) and a fixed interval (FI-60) and a schedule of discriminated avoidance response (DAR) were used for the conditioned behaviors. In the FR-30 and FI-60 schedules, B₁, B₁-P and B₁-PP administered intraventricularly 10-50 μg/rat or subcutaneously 100-200 mg/kg, produced the dose-related decreases in the behaviors. In the DAR schedule, B₁, B₁-P and B₁-PP did not produce significant alteration. The suppressive effect in the food reinforcement schedule by B₁, histamine B₁-P and B₁-PP was partially antagonized by the simultaneous administration of tripelennamine, an antihistaminic. A large dose of B₁caused an elevation of histamine level in the brain of mouse approximately 25%. From these results, a possibility that the suppressive effect of B₁on the operant behaviors may be responsible for histamine in the brain, is discussed.

ラットオペラント行動に及ぼすビタミンB<SUB>1</SUB>および関連物質の影響

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