The mechanism of antithrombogenicity of urokinase immobilized polyurethane - Effects on platelet adhesion.

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  • ウロキナーゼ固定化材質の抗血栓性発現機序について
  • effects on platelet adhesion

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Abstract

Urokinase (UK) immobilized material is known to have excellent antithrombogenicity. This antithrombogenicity has been ascribed to the fibrinolytic activity of plasmin activated by UK.<br>We found that platelet adhesion was not recognized on the surface of UK immobilized polyurethane catheter indwelled in vein. To investigate the interaction between platelet adhesion and fibrinolytic activity, inactivated immobilized UK was prepared by chemical modification with (p-amidinophenyl) methanesulfonyl fluoride hydrochloride. Polyurethane, UK immobilized polyurethane and inactivated UK immobilized polyurethane were incubated with human blood in Chandler loop and their surface were observed by scanning electronmicroscopy. Platelet adhesion on the surface of the material was recognized for polyurethane but not observed for UK immobilized polyurethane and inactivated UK immobilized polyurethane.<br>We concluded that the antithrombogenicity of UK immobilized material depends not only on fibrinolytic activity but also inhibition of platelet adhesion which is not mediated with plasminogen activation by urokinase.

Journal

  • Blood & Vessel

    Blood & Vessel 18 (3), 264-266, 1987

    The Japanese Society on Thrombosis and Hemostasis

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