Distributions of Steroid 5.ALPHA.-Reductase and 17.ALPHA.-Hydroxylase/C17,20-lyase (P450c17) Immunoreactivities in Rat Gastric Mucosa
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- Yokoi Hiromichi
- Department of Anatomy and Cell Biology, Institute of Health Biosciences, The University of Tokushima Graduate School Kagawa National Children's Hospital
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- Tsuruo Yoshihiro
- Departmemt of Anatomy and Cell Biology, Wakayama Medical University School of Medicine
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- Kominami Shiro
- Faculty of Integrated Arts and Sciences, Material and Life Sciences, Hiroshima University
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- Yamazaki Takeshi
- Faculty of Integrated Arts and Sciences, Material and Life Sciences, Hiroshima University
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- Ishimura Kazunori
- Department of Anatomy and Cell Biology, Institute of Health Biosciences, The University of Tokushima Graduate School
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説明
We examined the immunohistochemical localization of steroid 5α-reductase type 1 and 17α-hydroxylase/C17,20-lyase (P450c17) in rat gastric mucosa. Immunoreactivity of 5α-reductase was localized in the chief cells and the mucous neck cells. P450c17 immunoreactivity was localized in the parietal cells. Subcellular localizations of both 5α-reductase and P450c17 were on the membrane of endoplasmic reticulum. P450c17 is a key enzyme of androgen biosynthesis, and 5α-reductase has a high affinity for testosterone and catalyzes the conversion of testosterone to its 5α-reduced metabolite. Thus, it is suggested that there is an androgenic metabolic pathway in rat gastric mucosa.<br>
収録刊行物
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- Ａｃｔａ Ｈｉｓｔｏｃｈｅｍｉｃａ ｅｔ Ｃｙｔｏｃｈｅｍｉｃａ
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Ａｃｔａ Ｈｉｓｔｏｃｈｅｍｉｃａ ｅｔ Ｃｙｔｏｃｈｅｍｉｃａ 38 (1), 61-67, 2005
日本組織細胞化学会
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詳細情報 詳細情報について
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- CRID
- 1390001204862484224
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- NII論文ID
- 110003161230
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- NII書誌ID
- AA00508022
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- ISSN
- 13475800
- 00445991
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- 本文言語コード
- en
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- データソース種別
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- JaLC
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