Coregulator-Related Diseases

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  • YANASE Toshihiko
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University
  • ADACHI Masahiro
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University
  • GOTO Kiminobu
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University
  • TAKAYANAGI Ryoichi
    Department of Geriatric Medicine, Graduate School of Medical Science, Kyushu University
  • NAWATA Hajime
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University

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説明

Coregulators are a group of proteins, which modulate the nuclear receptor transactivation function. In this study, a new “coregulator disease” concept was proposed from observations of a case of androgen insensitivity syndrome (AIS) and cases involving Rubinstein-Taybi syndrome and X-linked dementia and hypothyroidism syndrome. In addition, coregulators are thought to be closely associated with the pathogenesis of several diseases such as hormone-dependent cancers and leukemia. Based on these observations, the clinical disorders associated with some coregulator abnormalities were reviewed.

収録刊行物

  • Internal Medicine

    Internal Medicine 43 (5), 368-373, 2004

    一般社団法人 日本内科学会

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