Serum Levels of KL-6 Reflect Disease Activity of Interstitial Pneumonia Associated with ANCA-related Vasculitis.

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  • IWATA Yasunori
    the Department of Gastroenterology and Nephrology, Kanazawa University
  • WADA Takashi
    the Department of Gastroenterology and Nephrology, Kanazawa University
  • FURUICHI Kengo
    the Department of Gastroenterology and Nephrology, Kanazawa University
  • KITAGAWA Kiyoki
    the Department of Gastroenterology and Nephrology, Kanazawa University
  • KOKUBO Satoshi
    the Department of Gastroenterology and Nephrology, Kanazawa University
  • KOBAYASHI Motoo
    the Department of Gastroenterology and Nephrology, Kanazawa University
  • SAKAI Norihiko
    the Department of Gastroenterology and Nephrology, Kanazawa University
  • YOSHIMOTO Keiichi
    the Department of Gastroenterology and Nephrology, Kanazawa University
  • SHIMIZU Miho
    the Department of Gastroenterology and Nephrology, Kanazawa University
  • KOBAYASHI Ken-ichi
    the Department of Gastroenterology and Nephrology, Kanazawa University
  • YOKOYAMA Hitoshi
    Division of Blood Purification, Kanazawa University

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Objective KL-6 is reported to be excreted from the lung alveolar and bronchial epithelial cells and may be a good marker for monitoring disease activity of interstitial pneumonia. This study was designed to ascertain the clinical significance of serum KL-6 levels in interstitial pneumonia associated with anti-neutrophil cytoplasmic antibody (ANCA)-related vasculitis.<br> Methods Serum KL-6 levels were determined by an enzyme-linked immunosorbent assay.<br> Patients We examined 20 healthy subjects, 13 patients with perinuclear (myeloperoxidase, MPO) ANCA-related vasculitis and 12 dermatomyositis (DM)/polymyositis (PM) patients as disease controls in this study. Six out of 13 patients with ANCA-related vasculitis had interstitial pneumonia.<br> Results Serum levels of KL-6 in ANCA-positive patients with interstitial pneumonia were significantly elevated, while they remained as low as those of healthy subjects in ANCA- positive patients without interstitial pneumonia. Similarly, KL-6 levels in sera were higher in 12 dermatomyositis/polymyositis patients with interstitial pneumonia, while they remained low in DM/PM patients without interstitial pneumonia. Moreover, the elevated serum KL-6 level was reduced during the convalescence induced by glucocorticoid therapy and reflected the disease activity of interstitial pneumonia associated with ANCA-related vasculitis.<br> Conclusion These data suggest that the measurement of serum KL-6 levels may be a good monitoring system for the diagnosis and follow-up of interstitial pneumonia of patients with ANCA-related vasculitis.<br>(Internal Medicine 40:1093-1097, 2001)

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  • Internal Medicine

    Internal Medicine 40 (11), 1093-1097, 2001

    一般社団法人 日本内科学会

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